Do CAD genetic risk scores predict cardiovascular risk?

CAD genetic risk scores (GRSs) predict risk independently from clinical tools, like QRISK3. We assessed the added value of GRSs for a variety of cardiovascular traits (CV GRSs) for predicting CAD and MACE and tested their early-life screening potential by comparing against the CAD GRS only.

Is CAD genetic risk stratification a good idea?

Coronary artery disease (CAD) and major adverse cardiovascular events (MACE) are the leading causes of death in the general population, but risk stratification remains suboptimal. CAD genetic risk scores (GRSs) predict risk independently from clinical tools, like QRISK3.

Can ml predict CAD?

Using an ML approach provides the ability to predict the presence of CAD with high accuracy and recall, and thus allows practitioners to practice preventative medicine in patients with CAD in a timelier manner. However, at such initial stages, it should be noted that ML serves solely as a predictor of CAD rather than a diagnostic tool.

What does CAD stand for?

Figure 1. Flowchart indicating the number of individuals included in the study and the partition into training and test for coronary artery disease (CAD) and major adverse cardiovascular event (MACE) end points.